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Macrocycle Synthesis A Practical Approach (The Practical Approach in Chemistry Series) by David Parker

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Published by Oxford University Press, USA .
Written in English


Book details:

The Physical Object
Number of Pages272
ID Numbers
Open LibraryOL7400978M
ISBN 100198558406
ISBN 109780198558408

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Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction to this important class of molecules and describes how to synthesize them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesized over the past few decades are covered Cited by: With chapters contributed from leading international figures involved in macrocyclic drug discovery efforts, the book is broken into four parts: challenges specific to macrocycles, classes of macrocycles and their potential in drug discovery, the synthetic toolbox for macrocycles, and case studies of macrocyclic marketed drugs and clinical cturer: Wiley. Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction this important class of molecules and describes how to synthesise them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesised over the past few decades are covered. Macrocycle Synthesis: A Practical Approach (The Practical Approach in Chemistry Series) by David Parker and a great selection of related books, art and collectibles available now at

"Macrocycle synthesis: a practical approach is an essential and detailed guide for all those engaged in the synthesis of macrocyclic compounds and interested in their coordination chemistry. It will appeal to the specialist and non-specialist alike, and should serve as an ideal introduction and companion for newcomers to the field."--Jacket.   About this book Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. About this book Written by internationally acclaimed experts, this handy volume covers all major classes of supramolecular compounds. Chapters include cyclophanes, resorcinarene and calixarene synthesis, supramolecular metallomacrocycles and macrocycle synthesis, rotaxane and catenane synthesis, cucurbiturils and porphyrins, as well as. a book like Macrocycle synthesis is a modern necessity in the Practical approach in chemistry series from OUP This is the gateway to unnatural macrocycle synthesis for the novice - enter here and a wonderful repertoire of useful structures will, with practice and training, come within : Spiral-bound.

The 3 + 1 synthesis of the title macrocycle frameworks contg. two imidazolium moieties linked in a 1,3-alternating manner can be controlled by the presence of chloride anions, such as Bu4N+ Cl-. Moreover, the halide anions generated in situ during macrocyclization act as by: 6. Written by internationally acclaimed experts, this handy volume covers all major classes of supramolecular compounds. Chapters include cyclophanes, resorcinarene and calixarene synthesis, supramolecular metallomacrocycles and macrocycle synthesis, rotaxane and catenane synthesis, cucurbiturils and porphyrins, as well as macrocyclic drugs. Each chapter contains experimental . The book is a well-made snapshot of current research, describing development stories of established macrocycle drugs and their properties, as well as new avenues in their development. The book's 11chapters, written by distinguished experts, are mostly dedicated to macrocycles for a specific protein target or target : $ Abstract We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAMs). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional by: 5.